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单核细胞趋化蛋白-1与动脉粥样硬化斑块不稳定关系的临床研究——附25例检测报告 被引量：4

A clinical study on relationship between monocyte chemoattractant protein-1 and unstable atherosclerotic plaques.
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摘要 　目的: 探讨血清单核细胞趋化蛋白 1 (monocytechemoattractantprotein 1, MCP 1) 水平与冠状动脉不稳定斑块的关系。方法: 应用酶联免疫吸附法分别检测A组 25例急性心肌梗死, B组 26例稳定型心绞痛患者血清MCP 1水平。结果: 治疗前A组单核细胞趋化蛋白 1水平 (21 8±2 6) ng/L较B组 (15 8±2 1)ng/L明显增高, 两组比较差异有统计学意义; A组患者发病前后差异 [ ( 21 8±2 6 )ng/L比 (17 3±2 3)ng/L] 亦有统计学意义, 均为P<0 05。结论: 急性心肌梗死患者血清MCP 1水平明显增高, 是显示斑块不稳定性的重要标志之一。 Objective: To study the relationship between serum monocyte chemoattractant protein-1(MCP-1) level and instability of atherosclerotic plaques. Methods: Serum MCP-1 was measured by means of enzyme linked immonosorbent assay(ELISA) in 25 patients with acute myocardial infarction(AMI) in group A and in 26 patients with stable angina pectoris in group B. Results: Serum MCP-1 level was significantly higher in AMI group[(21.8±2.6)ng/L] than that in the stable angina group[(15.8±2.1)ng/L] before treatment(P<0.05).Serum MCP-1 level was significantly reduced in patients with AMI after treatment(P<0.05). Conclusions: Serum MCP-1 level is elevated in acute myocardial infarction, indicating its role as a marker predicting the rupture of unstable plaques.
作者 仲琳 张运 陈文强 刘少荣 刘文波
机构地区 山东大学齐鲁医院心内科 山东烟台毓璜顶医院心内科
出处 《新医学》 北大核心 2005年第1期18-19,共2页 Journal of New Medicine
基金 卫生部临床学科重点项目 (No20012943)
关键词 单核细胞趋化蛋白-1 患者 血清 MCP-1 动脉粥样硬化斑块 急性心肌梗死 增高 in- 差异 意义 Monocyte chemoattractant protein-1 Arteriosclerosis Myocardial infarction Stable angina pectoris Unstable plaque
分类号 R543 [医药卫生—心血管疾病] R542.22 [医药卫生—心血管疾病]
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参考文献10

  • 1赵强,陈国伟.不稳定型心绞痛患者血清基质金属蛋白酶水平的临床意义——附45例检测报告[J].新医学,2004,35(8):461-463. 被引量：15
  • 2许文亮,郭新贵,徐延路,林宪如,何涛.冠心病患者血浆胆固醇与内皮素-1 C-反应蛋白及血小板可溶性P选择素相关性研究──附56例报告[J].新医学,2004,35(6):330-331. 被引量：25
  • 3Libby P, Ridker PM, Maseri A. Inflammation and atherosclerosis. Circulation, 2002, 105 (9) : 1135-1143.
  • 4Davies ,MJ. Pathophysiology of acute coronary syndromes. Heart, 2000, 83(3) : 361-366.
  • 5Kim WJ, Chereshnev I, Gazdoiu M, et al. MCP-I deficiency is associated with reduced intimal hyperplasia after arterial injury. Biochem Biophys Res Commun, 2003, 310 (3) : 936-942.
  • 6Werle M, Schmal U, Hanna K, et al. MCP-I induces activation of MAP-kinases ERK, JNK and p38 MAPK in human endothelial cells. Cardiovasc Res, 2002, 56 (2) : 284-292.
  • 7Hoffman M, Blum A, Baruch R, et al. Leukocytes and coronary, heart disease. Atherosclerosis, 2004, 172 ( 1 ) : 1- 6.
  • 8de Lemos JA, Morroco DA, Sabatine MS, et al. Association between plasma levels of monocyte chemoattractant protein-1 and long-term clinical outcomes in patient with acute coronary sundromes. Circulation, 2003, 107(5) : 690- 695.
  • 9Davies ,MJ. Pathophysiology, of acute coronary syndromes. Heart, 2000, 83(3) : 361-366.
  • 10de Lemos JA, Morroco DA, Sabatine MS, et al. Association between plasma levels of monocyte ehemoattractant protein-1 and long-term clinical outcomes in patient with acute coronary sundromes. Circulation, 2003, 107(5) : 690- 695.

二级参考文献22

  • 1Fu T, Borensztajn J. Macrophage uptake of low-density lipoprotein bound to aggregated C-reactive protein: possible mechanism of foam-cell formation in atherosclerotic lesions. Biochem J, 2002, 15 (366 Pt 1): 195-201.
  • 2Tokumura A, Sumida T, Toujima M, et al. Platelet-activating factor (PAF) -like oxidized phospholipids: relevance to atherosclerosis. Biofactors, 2000, 13 (1-4): 29-33.
  • 3Naqvi TZ, Shah PK, Ivey PA, et al. Evidence that high-density lipoprotein cholesterol is an independent predictor of acute platelet-dependent thrombus formation. Am J Cardiol, 1999, 84 (9): 1011-1017.
  • 4Fan J, Unoki H, Iwasa S, et al. Role of endothelin-1 in atherosclerosis.Ann N Y Acad Sci, 2000, 902 (1): 84-93.
  • 5Kinlay S, Behrendt B, Wainstein M, et al. Role of endothelin-1 in the active constriction of human atherosclerotic coronary arteries. Circulation,2001, 104 (10): 1114-1118.
  • 6Zouridakis EG, Schwartzman R, Garcia-Moll X, et al. Increased plasma endothelin levels in angina patients with rapid coronary artery disease progression. Eur Heart J, 2001, 22 (17): 1578-1584.
  • 7Blackburn R, Giral P, Bruckert E, et al. Elevated C-reactive protein constitutes an independent predictor of advanced carotid plaques in dyslipidemic subjects. Arterioscler Thromb Vasc Biol, 2001, 21 (12): 1962-1968.
  • 8Jonkers IJ, Mohrschladt MF, Westendorp RG, et al. Severe hypertriglyceridemia with insulin resistance is associated with systemic inflammation:reversal with bezafibrate therapy in a randomized controlled trial. Am J Med, 2002, 112 (4): 275-280.
  • 9Frohlich M, Imhof A, Berg G, et al. Association between C-reactive protein and features of the metabolic syndrome: a population-based study. Diabetes Care, 2000, 23 (12): 1835-1839.
  • 10Yamada S, Gotoh T, Nakashima Y, et al. Distribution of serum C-reactive protein and its association with atherosclerotic risk factors in a Japanese population: Jichi Medical School Cohort Study. Am J Epidemiol, 2001,153 (12): 1183-1190.

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新医学
2005年 第1期

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