针刺对抑郁症模型大鼠行为学的影响

Effect of Acupuncture in Inhibiting Behavior of Rats with Depression

目的 观察针刺对抑郁症模型大鼠行为学的影响。方法 选择Open Field法评分相近的 5 0只成年SD雄性大鼠随机分为正常对照组、模型组、空白对照组、药物组、针刺组 ,每组各 10只。应用分养和长期不可预见性中等强度应激造成抑郁症模型大鼠。以Open Field法和糖水消耗实验对照研究针刺对慢性应激诱导的抑郁症模型大鼠行为学的改变。结果 与正常对照组比较 ,模型组大鼠Open Field评分降低 ,糖水消耗量减少 ;与空白对照组比较 ,各治疗组大鼠在治疗过程中Open Field评分升高 ,糖水消耗量增加 ;而针刺治疗与药物治疗在行为学评价方面无显著性差异。结论 实验结果提示针刺治疗可以改变分养和长期不可预见性中等强度应激诱导的抑郁症模型大鼠的行为学异常 。

OBJECTIVE To observe the effect of acupuncture in inhibiting the behavior of rats with depression. METHOD 50 male adult rats with similar Open-field rating were randomly divided into a normal control group, a model group, a blank control group, a medication group and an acupuncture group, with 10 rats in each group. Long-term unpredictable medium irritability was given to cause depression. Then, Open-field method and sweet water consumption experiment were employed to observe changes in the rats’ behavior. RESULT Compared with the normal control group, the Open-field ratings and sweet water consumption in the model group decreased; compared with the blank control group, the Open-field ratings and sweet water consumption in the treatment groups increased; there is no marked difference between the acupuncture group and the medication group. CONCLUSION Acupuncture treatment can modify the behavior abnormality of rats, the effect of which is similar to that of fluoxetine.