谷氨酰胺对运动性免疫抑制的干预作用及其机制的研究

Research on Intervenient Effects and Mechanism of Glutamine on Exercise-induced Immunity Suppression

进一步研究运动性免疫抑制的机制 ,探讨谷氨酰胺 (Gln)在运动性免疫抑制发生中的作用 ,以及 Gln对运动性免疫抑制的干预作用及其机制。通过对大鼠进行为期 8周、每周 6次 ,每次 15 0 min的游泳训练 ,建立运动性免疫抑制的模型 ,并补充 Gln,测定机体淋巴细胞的增殖功能、细胞因子等免疫指标的变化、血清 Gln含量以及淋巴细胞凋亡的变化。研究结果表明 ,长期大负荷训练可以导致机体细胞免疫功能的显著降低 ;长期大负荷的运动训练可以导致血清 Gln含量的降低 ,引起机体抗氧化能力降低和外周淋巴细胞凋亡增加 ,可能是大负荷训练导致机体免疫功能降低的重要机制 ;在大负荷训练后补充 Gln可以有效地调节和提高训练机体的免疫功能 ,预防运动性免疫抑制的发生。

To further explore the mechanism of exercise-induced immunity suppress ion and discuss the effects and mechanism of glutamine on modulation of immunity function.Exercise immunity suppression model is established by SD rats,which conduct 150 minute per day,6 days per week swimming training for 8 weeks.Meanw hile,the rats are administrated for Gln.The immunity indexes including Iymphoc ytic proliferation function,serum cytokin concentration,serum glutamine level and apoptosis of lymphocyte in peripheral blood are determined.The result shows that long-term maximal training may result in the decrease of immunity functio n significantly.The decrease of serum Gln may result in oxidation resistance red uction to increase lymphocytic apoptosis in peripheral blood after long-term ma ximal training.It is on e of important mechanism of exercise immunity suppression.Supplement of Gln aft er maximal training may modulate and enhance the immunity function in training, prevent the occurrence of exercise-induced immunity suppression effectively.