老年颈动脉粥样硬化患者血清胆固醇、C-反应蛋白与缺血性卒中的相关性研究

Evaluation of correlations between the serum choksterols, CRP and ischemk stroke in elderly carotid atherosclerosis patients

目的 研究老年颈动脉粥样硬化的临床意义及与缺血性卒中的关系,并探讨其血清胆固醇(TC),低密度脂蛋白胆固醇(LDL-C)及C-反应蛋白(CRP)各项指标在动脉粥样硬化发生发展中的作用。方法 对具有不同脑血管病危险因素的90例老年患者作双侧颈动脉超声检查,按危险因素的多少分为高危组54例和低危组36例,另设正常老年人20例为对照组,同时进行血清TC、LDL-C、CRP检测及头颅CT扫描。结果 高危组与低危组比较,颈动脉内-中膜厚度(IMT),斑块发生率及卒中发生率分别为P<0.05、P<0.005、P<0.005,有显著性差异。低危组与对照组比较,分别为P<0.05、P<0.05、P<0.05,有显著性差异。在血清TC、LDL-C及CRP检测中,高危组与低危组相比,分别为P>0.2、P<0.05、P<0.05、后两者有显著性差异;低危组与对照组相比,分别为P>0.5、P<0.05、P<0.05,后两者有显著性差异。结论 多重危险因素的共同作用决定了颈动脉粥样硬化的程度并加重了缺血性卒中的发生。LDL-C及炎症因素促进和参与了动脉粥样硬化的发展。颈动脉B超、LDL-C及CRP对缺血性卒中的预测和防治有重要意义。

Objective To study the clinical significance of carotid atherosclerosis and the relationship between carotid atherosclerosis and ischemic stroke. Methods 90 elderly patients with cerebrovas-cular disease risks and 20 normal subjects were detected by the carotic color ultrasonography, the cranial CT and the serum TC, LDL-C, CRP were analysed. Results In the patients group that the thickness of IMT of carotid were significantly increased, the incidence of atherosclerosis plaque and the incidence of ischemic stroke were significantly increased. The level of LDL-C. CRP were significantly higher in the high risk group than in the low risk group (P<0. 005). The level of LDL-C. CRP were also higher in the low risk group than in the normal group(F<0. 005). Conclusions The multiple risk factors can take great role in the development of the carotid atherosclerosis and increase the incidence of ischemic stroke. LDL-C and inflammatory factors take part in and develop the carotid atherosclerosis. LDL-C and CRP have important value in prediction, prevention and treatment in the ischemic stroke.