对氧磷酯酶-1与老年人2型糖尿病视网膜病变的关系被引量：5

The relationship between paraoxonase-1 activity and type 2 diabetes mellitus retinopathy in the elderly

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摘要目的探讨血清对氧磷酯酶1(PON1)活性与老年人2型糖尿病(T2DM)并发视网膜病变(DR)的关系。方法血清PON1活性用酚乙酸酯为底物测定。血浆氧化型低密度脂蛋白(oxLDL)用ELISA法测定。结果老年单纯T2DM组PON1活性为(9608±3143)kU/L,比健康对照组显著降低〔(13028±1948)kU/L,P<001〕,T2DM并发DR组PON1活性(7453±1679)kU/L,比老年单纯T2DM组显著降低(P<001)。oxLDL浓度在老年单纯T2DM为(6996±841)μg/L,比健康对照组显著升高〔(4264±763)μg/L,P<001〕,老年人T2DM并发DR组oxLDL浓度为(8123±849)μg/L比老年单纯T2DM组显著升高(P<001)。PON1活性与oxLDL的浓度呈高度负相关(r=-084,P<001),Logistic回归分析表明PON1活性是T2DM并发DR的高度危险因素(P<001)。结论PON1活性在T2DM显著下降,且在并发T2DM患者下降更显著。PON1活性与oxLDL呈负相关。PON1活性降低是T2DM并发DR的高度危险因素。 Objective To investigate the relationship between paraoxonase-1 (PON-1) activity and type 2 diabetes mellitus (T2DM) retinopathy (DR) in the elderly. Methods Serum PON-1 activity was assayed using phenylacetate as the substrate and plasma oxidized low-density lipoprotein (ox-LDL) was determined by ELISA. Results PON-1 activity was much lower in the elderly group with T2DM than that of the controls 〔(96.08±31.43) kU/L vs.(130.28±19.48)kU/L, P<0.01〕 and PON-1 activity was (74.53±16.79)kU/L in the patients with T2DM complicated with DR, much lower than that of the patients with simplex T2DM(P<0.01). Plasma ox-LDL level was increased in the elderly groups with T2DM than that of the controls 〔(699.6±84.1)μg/L vs. (426.4±76.3)μg/L, P<0.01〕 and ox-LDL level was much higher in DR group (812.3±84.9) μg/L than that of the patients with simplex T2DM (P<0.01). There was significant negative correlation between serum PON-1 activity and level of ox-LDL (r=-0.84, P<0.001). Logistic regression analysis results suggested that PON-1 activity should be an independent risk factor of DR (P<0.01). Conclusions Serum PON-1 activity is significantly decreased in patients with T2DM especially patients with T2DM complicated with DR. Negative correlation exists between PON-1 activity and plasma ox-LDL level. The decrease of PON-1 activity is an independent risk factor of DR of patients with T2DM.

作者蒲霞曾繁荣曾昭淳刘万里

机构地区重庆医科大学附属第一医院老年科重庆医科大学生化教研室

出处《中国老年学杂志》 CAS CSCD 北大核心 2005年第1期21-23,共3页 Chinese Journal of Gerontology

关键词糖尿病非胰岛素依赖型糖尿病视网膜病变对氧磷酯酶-1 氧化型低密度脂蛋白 Diabetes mellitus, non-insulin-dependent diabetic Diabetic mellitus retinopathy Paraoxonase 1(PON-1) Oxidized low-density lipoproteins (ox-LDL)

分类号 R587.1 [医药卫生—内分泌]

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