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丙氨酸氨基转移酶持续正常的慢性丙型肝炎病毒感染的研究进展 被引量：2

Chronic hepatitis C viral infection with persistent normal serum alanine aminotransferases
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摘要 丙型肝炎病毒(HCV)感染极易慢性化,研究表明,约有20%～30%的HCV慢性感染患者丙氨酸氨基转移酶(ALT)持续正常,临床症状缺失或非常轻微.所谓ALT持续性正常,即为在6个月内间断1个月以上复查3次,ALT均在正常范围以内.对于此类患者是否进行抗病毒治疗一直存在争议[1,3].现就ALT持续性正常HCV感染的自然病史、肝脏病理变化、病毒载量、免疫反应和抗病毒疗效的研究进展进行概述.
作者 黄长形 白雪帆
机构地区 第四军医大学唐都医院全军感染病诊疗中心
出处 《中华肝脏病杂志》 CAS CSCD 北大核心 2005年第1期70-71,共2页 Chinese Journal of Hepatology
关键词 正常 ALT 丙氨酸氨基转移酶 慢性丙型肝炎病毒感染 HCV 患者 研究进展 缺失 变化 持续性 Hepatitis C virus Chronic hepatitis C Liver function tests
分类号 R512 [医药卫生—内科学] R446 [医药卫生—诊断学]
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参考文献10

  • 1Marcellin P, Levy S, Erlinger S. Therapy of hepatitis C: patients with normal aminotransferase levels. Hepatology, 1997, 26(suppl 1): 133S-136S.
  • 2Shiffman ML, Stewart CA, Hofmann CM, et al. Chronic infection with hepatitis C virus in patients with elevated or persistently normal serum alanine aminotransferase levels: comparison of hepatic histology and response to interferon therapy. J Infect Dis, 2000,.
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同被引文献11

  • 1潘克女,张永乐,任绪义,陈刚,刘宝根.定量聚合酶链反应在丙型肝炎病毒感染检测中的应用及临床意义[J].浙江临床医学,2006,8(11):1213-1213. 被引量：7
  • 2周远青,梁瑞莲,梁玉全,叶佩玑,刘建辉.丙型肝炎患者血清HCVRNA含量与抗HCV和ALT的相关性[J].中国实验诊断学,2006,10(12):1397-1399. 被引量：12
  • 3赵辉,谢尧,李明慧,徐道振,陆志檬,骆抗先,贾继东,王宇明,赵桂珍,张树林,张大志.慢性丙型肝炎患者的血清HCV基因型和RNA含量与ALT和AST水平不相关[J].中华检验医学杂志,2007,30(6):631-634. 被引量：33
  • 4Stephen L, Chen, Timothy R, Morgan. The natural hlstory of hepatitis C Virus (HCV) infection [J]. Int J Meg Sci , 2006 ; 3(2) :47 -52
  • 5Sabin CA, Emery V, Devereux HL, et al. Long - term patterns of hepatitis C virus RNA concentrations in a cohort of HIV seronegative men with bleeding disorders [ J ]. J Med Virol,2002;68( 1 ) :68 -75
  • 6Selcuk Kaya, Emel Sesli Cetin, Buket Cicioglu Aridogan, et al. Adenosine deaminase activity in serum of patients with hepatitis - a useful tool in monitoring clinical status [ J ]. J Microbiol Immunol Infect, 2007 ; 40 (4) : 288 - 292
  • 7Perrillo RP. The role of liver biopsy in hepatitis C [ J ]. Hepatology, 1997 ;26(3 Suppl 1 ) :57S -61S
  • 8Giannini E,Botta F,Testa E,et al. The 1 -year and 3 - month prognostic utility of the AST/ALT ratio and model for end - stage liver disease score in patients with viral liver cirrhosis [ J ]. Am J Gastroenterol,2002 ; 97 ( 11 ) : 2855 - 2860
  • 9Ustundag Y, Bilezikei B, Boyaeioglu S, et al. The utility of AST/ALT ratio as a noninvasive demonstration of the degree of liver fibrosis in chronic HCV patients on long - term haemodialysis [ J ]. Nephrol Dial Transplant, 2000; 15 (10) :1716 - 1717
  • 10Neumann UP, Berg T, Bahra M, et al. Fibrosis progression after liver transplantation in patients with recurrent hepatitis C[J]. J Hepatol,2004;41(5) :830 -836

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中华肝脏病杂志
2005年 第1期

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