施他宁治疗重症急性胰腺炎的临床观察

Clinical Evaluation of Stilamin in the Treatment of Severe Acute Pancreatitis

目的探讨施他宁治疗重症急性胰腺炎的临床效果。方法将38例重症急性胰腺炎病人随机分为施他宁治疗组(n=17)和对照组(n=21),观察了两组治疗前后血清淀粉酶及腹腔液淀粉酶的含量,并对比分析两组之间并发症的发生率、病死率、住院天数。结果治疗后施他宁治疗组的血清淀粉酶及腹腔液淀粉酶的含量明显低于对照组(p<0.05);施他宁治疗组患者的并发症、病死率、住院时间均低于对照组(p均<0.05)。结论施他宁能有效降低重症急性胰腺炎患者血清淀粉酶和腹腔液淀粉酶的水平,降低其并发症发生率及死亡率;施他宁对重症急性胰腺炎的治疗有重要价值。

Objective The clinical effects of stilamin in the treatment of patients with severe acute pancreati-tis were explored.Methods Thirty eight cases of severe acute pancreatitis were divided into stilamin treatment group(n=17)and control group(n=21)at random.Serum amylase and amylase of peritoneal exudates were quantita-tively analyzed.Contrast analyses were made between the groups on the incidence of complications,mortality,and the time of hospital stay.Results After therapy the contents of serum amylase and amylase of peritoneal exudates in stilamin group were lower significantly than those in control group(p<0.05);The incidence of complications and mortality of stilamin group were lower significantly than those of control group.And the time of hospital stay of stilamin group was shorter apparently than that of control group(P all<0.05).Conclu sions Stilamin could decrease significantly the levels of serum and pancreatic fluid amylase incidence of complication,and mortality of patients with severe acute pancreatitis;Stilamin is vital to treat severe acute pancreatitis.