抗溃疡候选药物Me-3407的合成

Synthesis of Me-(3407) as an Anti-Ulcer Drug Candidate

本文对抗溃疡侯选药物2 (噻唑[5,4 b]并吡啶 2 基 亚磺酰基)乙酸丁酯(Me 3407)的合成进行了研究。以文献方法为基础,烟酰胺为原料,通过五步反应生成目标化合物。并对最后一步氧化的合成工艺进行了改进,将反应条件优化,并提高了收率。

Synthesis of the anti-ulcer candidate drug,2-[(n-butoxycarbonylmethyl)sulfinyl]thiazolo-[5,4-b]pyridine,was analysed.The title compound was synthesized from niacinamide through five-step reaction according to the literature.The procedure of the last step was mended and the yield of the oxidation reaction was increased by optimizing the reaction conditions.