定量细胞核形态学在鉴别刮宫葡萄胎良恶性中的意义

THE VALUE OF QUANTITATIVE NUCLEUS MORPHOLOGY IN DISTINGUSHING HYDATIDIFORM MOLE FROM INVASIVE MOLE BY UTERINE CURRETAGE

用形态计量学方法对41例刮宫葡萄胎、35例首次刮宫的侵袭性葡萄胎和42例切除子宫的侵袭性葡萄胎进行了细胞核形态的定量研究。结果表明,3组葡萄胎细胞滋养细胞核的平均面积、平均周长、平均比表面及平均面积等效直径差异均有显著性(P<0.01～0.001);合体滋养细胞核各项形态学参数差异不明显。判别分析:首次刮宫葡萄胎组织良恶性诊断的符合率为84.5%。提示葡萄胎细胞滋养细胞核的形态学参数可作为区别葡萄胎良恶性的指标。与图像分析及传统病理组织分级方法比较表明,手工测试与图象分析同样可信,比传统病理组织分级方法更具有客观性和诊断价值。

Mean area(■x),mean perimetre(x),mean specific sur- face(■)and mean diameter of equivalent area(ea)of trophoblastic cells nucleus were measured by morphometric method in 41 cases of hydatidiform mole,in 35 cases the first curretage of invasive mole and 42 cases invasive mole。It was found that:(1)The difference of■x,x,andea of cytotro- phoblastic cell nucleus among three group were statistically significant(P< 0.01);the difference of■x,x,andea of syntrophoblastie cells nucleus was statistically significant(P<0.05)between the hydatidiform mole and the first curretage of invasive mole。(2)Discriminant analysis showed:corre- sponding:rate of diagnosis was 84.5% in hydatidiform mole from uterine cur- retage.This result suggests that morphologic parameter of cytotrophoblastic cell nucleus may be used as a means for distingushing hydatidiform mole from invasive mole.Manual morphometric method is believable to compair with image analysis.Diagnostic value of morphometric method is higher than traditional histopathological grade.