氯丙嗪、氯氮平对精神分裂症患者血清PRL的影响对照研究

A Control Study on Effects of Chlorpromazine and Clozapine on Serum Prolactin in Schizophrenia Patients

本研究观察精神分裂症或分裂样精神病患者在氯丙嗪或氯氮平治疗前后第 1、2、5周末的血清催乳素 ( s PRL) ,及 BPRS、SAPS、SANS评分 ,结果发现 ,病人组与对照组 s PRL无差异 ,氯丙嗪引起 s PRL显著升高 ,氯氮平则不影响 ;s PRL基础值与疾病严重程度无关 ,其基础值及治疗前后的变化不能预测临床疗效 ;氯丙嗪和氯氮平对精神分裂症的阴性阳性症状疗效均好 ,但长期治疗时氯丙嗪的阴性症状有加重趋势。

Serum prolactin(sPRL)level was measured in normal controls(n=18)and in patients suffering from schizophrenia or schizophreniform psychosis(n=33)before and at the 1st、2nd、5th weekend after chlorpromazine or clozpine treatment in this study.The Brief Psychiatric Rating Scale(BPRS).Scale for Assessment of Negative Symptoms(SANS)and Scale for Assessment of Positive Sympotoms(SAPS)were administered at the same time.We found no difference between mean sPRL values in patients and normal controls,and sPRL increased significantly after chlorpromazine treatment,but clozapine did not affect sPRL,there is significant difference between the tow groups.The baseline level of sPRL begore the treatment did not correlate with the severity of the illness.Neither the baseline level nor the changes of the sPRL after treatment could predict clinical response.Chlorpromazine and clozapine improved both negative and positive sympotoms of schizophrenia significantly,but the negative symptoms had an increasing trend after chronic chlorpromazine treatment.