白血病患者血浆抗凝纤溶及激肽释放酶原检测的意义

THE SIGNIFICANCE OF PLASMAT IC ANTICOAGULATION FIBRINOLYSIS AND PREKALLIKREIN IN PATIENT WITH LEUKEMIA

对白血病37例(急淋16例,急非淋14例,慢粒7例)进行抗凝,纤溶及激肽释放酶原的测定。结果抗凝血酶-Ⅲ抗原(AT-Ⅲ:Ag)、抗凝血酶-Ⅲ活性(AT-Ⅲ:C)及α_1-抗胰蛋白酶(α_1-AT)水平均降低,与对照组比较,均有显著差异(P<0.01)补体C_1-抑制物(C_1-INH)无差异(P>0.05)纤溶酶原抗原(PLG:Ag)三组水平降低,以急淋及慢粒组下降明显,差异非常显著(P<0.01),激肽释放酶原活性(PK:C):急淋水平增高,差异非常显著(P<0.01),急非淋及慢粒无差异(P>0.05)抗凝指标下降,示高凝状态;纤溶指标下降,示纤溶亢进,可视为白血病出血的原因。

Plasmatic anticoagulation, fibrinolysis and prekallikrein levels were examined in 37 cas- es of leukemia, including 16 cases of ALL, 14 ANLL and 7 CML. The result shows that AT-3:Ag. AT-3:C and α_1-AT levels are markedly lower than that of normal subjects (P< 0. 01). G--INH are not different from the controls (P>0. 05). PLG:Ag levels are markedly lower in all patients (P<0. 01). PK: C levels in ALL ptients are significantly high (p<0. 01). but not in ANLL and CML (p>0. 05). Our result shows that the decrease of anticoag- ulation indexes indicates the state of hypercoagulability, but the decrease of fibrinolysis in- dexes indicates hyperfibrinolysis, and it can be looked as the cause of hemorrhage of leukemi-