摘要
本文用细胞形态学、细胞化学、免疫分型、免疫球蛋白和T细胞受体基因重排及电镜过氧化物酶联合分析研究了40例难分类急性白血病(UAL)。结果发现,5例为ALL与AML误诊者,12例为杂合性急性白血病(HAL),11例为过氧化物酶阴性急性骨髓细胞白血病(MPO^--AML),12例为未分化型急性白血病(AUL)。HAL缓解率降,易伴有高WBC数和浸润体征,MPO^--AML易误诊,AUL为多系列细胞来源,并建议更加严格HAL和AUL的诊断标准。此外,作者还讨论了FAB分型和免疫分型等手段在白血病诊断分型上的作用并推荐联合用形态学、免疫学、分子生物学等多种手段研究分析UAL。
Morphological, immunological, molecular and myeloperoxidase with electron microscopy feature
of 40 patients with unclassified acute leukemia(UAL) were studied. The result showed five cases were
misdiagnosed betwen ALL and AML, twelve patients were considered as HAL, eleven as MPO^- --
AML, and another twelve patients as AUL. HAL patients were easily associated with high leukocytes.
AUL patients had different cell origins. we think that much more strict criteria should be applied in
diagnosing HAL and AUL.
关键词
白血病
分类
诊断
免疫分型
Leukemia
diagnosis
phenotype
molecular
