摘要
过氧化物酶体增殖剂活化受体是一类核转录因子 ,具有多种有益的生理作用 :参与心脏能量代谢 ,增加胰岛素敏感性 ,阻断过度激活的肾素 血管紧张素系统和胰岛素抵抗形成的恶性循环 ,抑制炎症反应 ,改善心功能 ,提高血管顺应性、降低后负荷 ,对抗心肌重塑。缺血 /再灌注时过氧化物酶体增殖剂活化受体激动剂抑制心肌组织炎症细胞浸润 ,减轻心肌缺血 /再灌注损伤而保护心脏。
Peroxisome proliferator-activated receptors (PPASs),transcription factors belonging to the nuclear receptors family,play a critical role in the pathophysiology of cardiac remodeling.PPASs manipulate cardiac energy metabolism,downregulate inflammatory response,improve insulin resistance to break vicious cycle formed by overactivated rennin-angiotensin system(RAS) and insulin resistance,decrease peripheral vascular resistance to reduce afterload.PPASs agonists also reduce myocardial injury and dysfunction caused by ischemia/reperfusion.
出处
《心血管病学进展》
CAS
2005年第1期75-77,共3页
Advances in Cardiovascular Diseases
