891例急性呼吸道感染患者病毒病原学调查

The pathogens of acute upper respiratory viral infection in 891 children

目的 了解当前小儿急性呼吸道病毒感染病原学的状况。方法 选择 891例首都儿科研究所附属儿童医院内科门诊 2 0 0 2年 5月至 2 0 0 4年 4月临床拟诊急性病毒性呼吸道感染的患儿 ,做咽拭子病毒分离 ,进行合胞病毒(RSV)、腺病毒 (AdV)、流感病毒、副流感病毒、疱疹病毒病原学检测。结果 891例患儿中阳性 2 37例 ,总阳性率2 6 6 0 %。单项病毒感染中RSV占首位 ,为 73例 (30 80 % ) ;其次为甲3 型流感病毒 70例 (2 9 5 4 % ) ;乙型流感病毒4 0例 (16 88% ) ;副流感病毒Ⅰ 2 6例 (10 97% ) ;AdV 2 0例 (8 4 4 % ) ;副流感病毒Ⅲ 8例 (3 38% )。最少为疱疹病毒Ⅰ 3例 (1 2 7% )。混合感染 3例 (RSV +甲3 型流感病毒 1例、AdV +副流感病毒Ⅲ 1例、乙型流感病毒 +甲3 型流感病毒 1例 ) ,占 1 2 7%。结论 2 0 0 2年夏至 2 0 0 4年春北京儿科门诊急性呼吸道感染仍以RSV、流感病毒为冬春季节引起小儿急性呼吸道感染的主要病原。

Objective To investigate the pathogens of acute upper respiratory viral infection in children.Methods Overall 891 children with acute upper respiratory infection were involved in this study.The viral isolation from sputums were performed from May 2002 to Apr 2004,which included respiratory syncytial virus (RSV),influenza virus,parainfluenza virus,adenovirus (ADV) and herpes virus.Results The pathogenic virus was isolated from 237 cases.The percentage of RSV,influenza A 3 ,influenza B,parainfluenzaⅠ,ADV,parainfluenza Ⅲ and herpes simplex were 30 80%,29 54%,16 88%,10 97%,8 44%,3 38% and 1 27% respectively.The overlap infection of 2 kinds of virus was found in 3 cases.Total positive rate of viral infection accounted for 26 59%.Conclusion RSV and influenza virus are prevailing pathogens of community acquired acute upper respiratory infection in children in the past 2 years.