涎腺疾病手术前后尿液表皮生长因子测定的临床研究

A clinical study on changes of urinary EGF before and after surgery in patients with salivary gland diseases

目的 :评价涎腺疾病手术前后尿液表皮生长因子 (EGF)含量的变化。方法 :采用竞争性放射免疫分析方法对 3 3例涎腺疾病患者手术前后尿液EGF浓度进行测定。结果 :术前尿液EGF均值为 19.89μg/L ,术后为2 0 .64 μg/L ,正常对照组为 2 4.70 μg/L ,三者之间无显著性差异 (P >0 .0 5 )。腮腺和颌下腺手术前后尿液EGF浓度变化 ,腮腺术前 16.64 μg/L ,术后 17.16μg/L ,颌下腺术前 18.3 2 μg/L ,术后为 2 1.95 μg/L。腮腺和颌下腺手术前后EGF均无显著性差异 (P >0 .0 5 )。结论 :一侧腮腺颌下腺切除后其尿液EGF含量较术前略有代偿性增加 ,这对保护口腔组织具有重要意义。

Objective:to evaluate the changes of urinary EGF before and after surgery in patients with salivary gland diseases.Method: 33 cases and ten control subjects were enrolled in the study. Urine was collected before and after(weekly) operation and EGF concentrations were measured with the radioimmunoassay.Result:EGF levels decreased a little in patients group before(19.89 μg/L)and ofter(20.64 μg/L) than in cortrol group(24.70 μg/L) but its' levels increased a bit both parotid gland(17.16 μg/L) and submandibular gland (18.32 μg/L) there is no significant difference between two groups (P>0.05).Conclusion: The EGF levels of urine increased compensationally when a lateral parotid or submandibular gland resected which play an important role for EGF to protect the oral cavity .