摘要
P物质是一种多肽 ,广泛地分布于神经系统和其他外周组织器官内 ,具有多种生理功能。P物质可以影响淋巴细胞的增殖和细胞因子的合成 ,并能调节辅佐细胞合成细胞因子和其它一些免疫细胞的活性 ,从而参与免疫调节 ;P物质还调节生殖激素主要是促性腺激素的分泌 ,进而影响着生殖内分泌功能。另外 ,P物质在痛觉传递、胃肠运动、血管扩张、呼吸运动、伤口愈合等过程中都有重要作用 ,在机体的不同系统具有不同的生理学效应。表明P物质不仅是一种神经肽 ,也是一种传递信息、调节机体反应的重要信使物质。
Substance P is a kind of polypeptide, a lot of papers have showed that substance P is distributed in nervous system and other peripheral organs and tissues. Substance P has a variety of physiological functions, it can influence the proliferation and synthesis of cytokine of lymphocytes as well as regulate the activity and the synthesis of cytokine of accessory cells and other immunocyte, so substance P participates in the process of immune regulation. Moreover substance P mainly influences the secretion of gonadotropin-releasing hormone. In addition, subtance P has different effects in other systems such as pain conductivity, gastrointestinal function, vasodilator, respiratory activity, wound-healing and so on . All these indicate that substance P is not only a kind of neuropeptides but also an important messanger.
出处
《动物医学进展》
CSCD
2005年第1期6-8,共3页
Progress In Veterinary Medicine
关键词
P物质
免疫调节
生殖内分泌
细胞因子
substance P
immune regulation
reproductive endocrine
cytokine
