解脲脲原体与不育症的研究进展

Research Progress of Ureaplasma urealyticum Infection and Infertility

生殖道解脲脲原体 (Ureaplasmaurealyticum ,UU)感染影响了精子各项指标 ,降低精液整体质量。UU对精子活力影响最大 ,其次是精子数、成活率、顶体完整率、血清抗精子抗体。UU感染致使精子活力逐渐下降 ,最终导致精子死亡 ,从而降低精子成活率。UU感染引起血清IL 6升高 ,但并不能引起精浆IL 6升高。UU感染能降低精浆中Zn和Se的含量 ,从而也影响精液质量。动物模型中UU感染使精子头尾卷曲 ,尾部断裂、肿胀 ;影响细胞因子的分泌 ,使血清中细胞因子IL 6、IL 8含量有明显升高 ,但不能使TNF α、IFN α明显变化 ;对于睾丸、输精管、前列腺的形态组织结构尚未有明显的影响 ;UU感染导致泌尿生殖道中结石形成。总之 ,UU感染是引起男性不育的因素之一 。

Infection with Ureaplasma urealyticum(UU) leads to decline the quality of sperm, even to cause the death of sperm. UU infection causes the increase of the content of IL-6 in serum, while produces no effect on IL-6 in spermatic fluid. UU infection leads to the decrease of the content of Zn and Se in semen, therefore, the decline of spermatic quality. UU infection in animal models contributes to curl and break of the sperm, affects the secretion of cytokine, brings obvious change to the content of IL-6 and IL-8 in serum,but no obvious change to TNF-α and IFN-α.UU infection produces no obvious effect on the structures of testis, urethra and prostate but leads to the formation of calculus in urethra and bladder. In a word, UU infection is one of the factors that contribute to male infertility, the prompt treatment of which is advisable.