噬菌体在疾病治疗方面的应用及研究

Advances in Bacteriophage Therapy against Bacterial Disease

噬菌体治疗是利用噬菌体溶解细胞的作用而用于治疗人和动物的病原细菌的临床感染。早在 2 0世纪初 ,噬菌体治疗就取得过积极的治疗效果。目前针对传统抗生素治疗动物细菌感染时易产生残留及细菌耐药性等缺点 ,噬菌体治疗更表现出许多突出的优越性。基于大量的动物模型试验及人类临床治疗的实践 ,人们开始针对治疗中存在的缺点和不足 ,从治疗性噬菌体的选择、宿主谱、作用效力及其作用的动力学原理等方面 ,采用分子生物学等技术对噬菌体进行探索性的改造 ,以期获得更有效的治疗效果 。

Phage therapy is to treat bacterial clinical infections of human being and other animals with bacteriolysis. In the 1920's, Phage therapy had had efficiency in clinical treatment. Many creatural experiments and clinical treatments indicate that phage therapy is a potential alternative method for treatment and prevention of bacteria disease. This method comes along, quite opportunely to counter the resistance problem of the antibiotics. At present, molecular techniques have be considered to modify the phage in order to improve some defects such as the range of the host, efficiency and durative of the effect.Modified phage will be more effectual for protecting human and animals from bacterial infections.