血清IL-6、IL-8在急性心肌梗死缺血-再灌注过程中的动态变化及其临床意义

Study of dynamic changes and clinical singniticance of serum interleukin-6(IL-6) and interleukin-8(IL-8) in patients with acute myocardial infarction after myocadial ischemia and reperfusion

目的 :探讨血清IL 6、IL 8在急性心肌梗死 (AMI)早期及溶栓治疗过程中的动态变化及其意义。方法 :采用放射免疫分析法对 30例AMI患者入院当时、溶栓前及溶栓后不同时间点的血清IL 6、IL 8进行检测 ,分析其与心肌缺血 再灌注间的关系。结果 :与健康对照组相比 ,所有AMI患者的IL 6、IL 8水平于入院时即已开始升高 ,溶栓治疗后继续升高 ,其中IL 6高峰期在溶栓后 12～ 2 4小时 ,IL 8在 4～ 8小时 ;溶栓再通组升高更明显 (P <0 0 5 ) ;伴有心源性休克 ,急性心力衰竭及严重心律失常并发症的AMI患者较无并发症者增高明显 (P <0 0 5 )。结论 :观察细胞因子IL 6、IL 8动态变化规律有助于判定AMI病情及估价溶栓治疗效果。

Objective:To study the dynamic changes and clinical singniticance of interleukin 6(IL 6) and interleukin 8(IL 8) in serum of patients with acute myocardial infarction(AMI).Methods:Asynchronous serum IL 6 and IL 8 concentrations measured with radioimmunological assay in 30 patients with AMI from symptoms onset to thromblytic therapy finished and the datas were compard with 20 members of a healthy controlgroup,to investigate the relationship between the changes and myocardial ischemia/reperfusion.Results:The serum concentrations of IL 6 and IL 8 were elevated in all patients with AMI when compared with the healthy control group ( P <0 001),especially increased significantly in patients after thrombolytic therapy with reperfusion ( P <0 05),and the levels of IL 6 and IL 8 were found to be significantly higher in patients with complicated AMI than in patients with uncomplicated AMI ( P <0 05).Conclusion:Changes of IL 6 and IL 8 in serum of the patients with AMI were shown to be contributed to evaluate the severity of AMI and the effects of thromblytic therapy. [