部分性脾栓塞治疗脾功能亢进的疗效

Partial splenic embolization for the treatment of hypersplenism

目的 探讨部分性脾栓塞 (PSE)治疗脾功能亢进的临床应用价值及脾栓塞范围与疗效关系。方法 16例脾功能亢进患者分为两组 :第 1组 5例 ,脾栓塞范围 40 %～ 5 9% ;第 2组 11例 ,脾栓塞范围 60 %～ 80 % ,并随访 1年。结果 血小板计数两组近期缓解 (CR +PR)有效率分别为 81 3 % ,93 8% ;远期缓解有效率分别为 62 5 % ,87 5 % ;1年复发率分别为 2 3 1% ,6 7%。白细胞计数两组远期缓解有效率分别为 71 4% ,82 2 % ;1年复发率分别为 2 8 6% ,17 8%。红细胞计数两组远期缓解有效率分别为 70 % ,83 3 % ,1年复发率分别为 2 2 2 % ,11 8%。结论 PSE治疗脾功能亢进疗效好 ,脾亢复发率低。

Objective To study the clinical significance of partial splenic embolization (PSE) for the treatment of hypersplenism and the relationship between the therapeutic effect and the area of embolization. Methods Sixteen patients with hypersplenism were divided randomly into two groups: Group 1 (n=5) and Group 2 (n=11). The embolization area in Group 1 was 40%-59% and that in Group 2 was 60%-80%. A follow-up for 1 year was conducted in all patients. Results The short-term effective rates (CR+PR) of thrombocyte count were 81.3% in Group 1 and 93.8% in Group 2, respectively, whereas the long-term effective rates were 62.5% and 87.5%, respectively, and the corresponding one-year recurrence rates were 23.1% and 6.7%. The long-term effective rates of WBC count were 71.4% and 82.2% in groups 1 and 2, respectively, and the one-year recurrence rates were 28.6% and 17.8%, respectively. The long-term effective rates of RBC count were 70% in Group 1 and 83.3% in Group 2, respectively, and the one-year recurrence rates were 22.2% and 11.8 %, respectively. Conclusion PSE, resulting in a low recurrence rate, is effective in treating hypersplenism.