去交感神经状态对肝脏血流量的影响

Effects of denervation of sympathetic nerves on liver blood flow in rabbits

目的 探讨去交感神经状态对肝脏血流量的影响。方法 健康家兔 2 0只 ,分为 2组 :①正常组 ;②实验组为急性肝损伤组。两组分别行去交感神经处理。在注射 6 OHDA前 ,和注射后 3 0、60、12 0、180min分别测定血流参数 ,包括平均血流速度 (MBV)、平均血流量 (MBF)、血管阻力指数 (RI)和动脉搏动指数 (PI)。结果 去交感神经状态可使正常家兔肝动脉MBV和MBF升高 ,RI和PI降低 ;而门静脉血流参数无变化。在急性肝损伤的情况下 ,去交感神经状态可使肝动脉和门静脉MBV和MBF均升高 ,同时肝动脉RI和PI降低。结论 去交感神经状态可降低肝动脉血管阻力 ,使血流量增加 ;在急性肝损伤的情况下对门静脉亦有同样的影响。

Objective To observe the effects of sympathetic denervation of the liver on the blood flow in the normal and chemically injured rabbit liver. Methods Twenty healthy rabbits were divided evenly into 2 groups: control group and acute liver injury group (by Carbon Tetrachloride, CCL4). Chemical denervation was achieved by injection of 6-OHDA (2 ml, 100 mg/L) through the mesenteric vein of jejunum loop in rabbits in both groups. Mean blood flow velocity (MBV), mean blood flow (MBF), and resistant index (RI), and pulsant index (PI) of the artery were evaluated in every group before and at 30, 60, 120, and 180 min after injection, respectively. Results Chemical denervation led to significant increase of MBV and MBF, and decrease of RI and PI in the hepatic artery. However, the parameters of portal vein blood flow remained unchanged. However, under the condition of acute liver injury, chemical denervation led to significant increase of MBV and MBF for both the portal vein and hepatic artery, and decrease of RI and PI in the hepatic artery. Conclusion Sympathetic denervation can alleviate the vascular resistance and increase the blood flow in the hepatic artery. The same effect may be also found in the portal vein under the condition of acute liver injury.