摘要
目的:探讨树突状细胞(DC)在变应性鼻炎免疫调控中的作用。方法:采用细胞培养加酶联免疫吸 附试验(ELISA法)检测患者血液中Th1/Th2,观察DC对变应性鼻炎患者外周血Th1/Th2及相关细胞因子的调 控作用。结果:用成熟DC刺激后的培养上清液中IFN γ的浓度明显升高,Th1/Th2的比值有明显改变(P< 0.01)。结论:成熟DC能诱导Th1反应,调节Th1/Th2的比例,使Th0向Th1偏移分化,是治疗变态反应的一种 途径。
Objective:To investigate the immunoregulation of dendritic cells in allergic rhinitis.Method:Adopting the cell culture and the enzyme linked immunosorbant assay to examine the patients' Th 1/Th 2 in the blood. Observing that how is the DC's function in immunoregulation of allergic rhinitis.Result:The concentration of the IFN-γ advanced obviously in post-stimulatory supernatant liquid after using the mature DC.Conclusion:The mature dendritic cells can polarize naive T-cells into Th 1 effector cells, and are recognized as having a central role in the establishment of T-cell memory and peripheral immune tolerance.DC could be exploited as targets for therapy in asthma and allergic rhinitis.
出处
《临床耳鼻咽喉科杂志》
CAS
CSCD
北大核心
2005年第2期49-51,共3页
Journal of Clinical Otorhinolaryngology
基金
湖北省卫生厅基金资助项目(No:JX1B045)
关键词
鼻炎
变应性
常年性
树突状细胞
免疫调控
Rhinitis, allergic,perennial
Dendritic cells
Immunoregulation
