喘康颗粒抗炎作用研究

RESEARCH ON ANTI-INFLAMMATION EFFECT OF CHUANKANG GRANULE

目的 :研究喘康颗粒抗炎作用 ;方法 :采用二甲苯致小鼠耳廓肿胀、角叉菜胶致小鼠足跖肿胀、蛋清致大鼠足跖肿胀、醋酸致小鼠腹腔毛细血管通透性增加、小鼠棉球肉芽肿 ,对小鼠炎症组织炎症介质丙二醛及肝组织LPO含量的测定 ,进行抗炎作用试验 ,并对结果进行统计学检验 ;结果 :喘康颗粒较显著抑制二甲苯小鼠耳廓肿胀、非常显著抑制角叉菜胶致小鼠足跖肿胀、对蛋清性大鼠足跖肿胀有一定抑制 ,极显著抑制HAC致小鼠腹腔毛细血管通透性增高、显著抑制小鼠棉球肉芽肿。显著降低小鼠炎症组织炎症介质His、PGE、MDA含量 ;结论 :喘康颗粒具有较强的抗炎作用 ,显著降低炎症组织PGE和His含量 ,揭示喘康颗粒抗炎作用是其平喘作用机理之一。

Objective: To explore the Anti-inflammation effect of Chuankang Granule. Methods: Various inflammatory models, including, the swelling of ear induced by xylene in mice、the edema of hind paw induced by carrageenin in mice, the edema of hind paw caused by egg white in rats, the permeability of blood capillary increased by HAC in mice, etc. were used. Results: The experiments proved that Chuankang Granule had strong inhibition on many kinds of inflammatory models, and significantly decreased the contents of His、PGE and MDA in inflammatoy tissues in mice. Conclusion: Chuankang Granule has strong anti-inflammation effect, by decreasing significantly the content of His、 PGE and MDA. The experiments proved that the anti-inflammation of Chuankang Granule is one of the important mechanisms of controlling the attack of bronchial asthma.