解酒灵急性毒性和致突变性研究

STUDY ON ACUTE TOXICITY AND GENOTOXICITY OF JIEJIULING

目的 :对一种新的护肝解酒液解酒灵急性毒性和致突变性 (安全性 )进行研究。方法 :采用昆明种小鼠经口急性毒性试验、Ames试验、小鼠微核试验、小鼠精子畸变试验对其急性毒性和遗传毒性进行了测试。结果 :本检品对小鼠的急性经口LD5 0大于 12 .5g kg.bw ,判属实际无毒类。Ames试验、小鼠骨髓细胞微核试验和小鼠精子畸形试验 3项致突变性试验均为阴性结果 ,表明本检品无致突变性。结论 :解酒灵属实际无毒和无致突变性的护肝解酒液 ,具有保护肝免受酒精损害的功能 ,建议用于过量饮酒所致酒精中毒的护肝治疗。

Objective: To evaluate the safety of JIEJIULING, a liquid which protects liver from the alcohol damage. Methods: JIEJIULING was examined by the acute toxicity test, Ames test, micronuclei test of bone marrow cell and sperm shape abnormality test SD mice. Results: The results showed that the LD50 of JIEJIULING found more than 12.5g/kg body weight which is equal to no toxicity practically, was found in the three mutagenic tests and thus the liquid can be regarded as of no genotoxity. Conclusion: JIEJIULING has presumably no toxicity and genotoxicity, and it has the function of preventing the liver from alcohol damage.