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上皮型钙粘附素与食管癌临床病理特征关系的研究

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摘要 目的 :研究上皮型钙粘附素 (E -cadherin)在食管癌的表达水平及其与食管癌临床病理特征的关系。方法 :用免疫组化 (SP法 )法检测 6 0例食管癌组织和 2 0例远离癌组织的正常食管上皮组织中E -cadherin的表达水平。结果 :食管癌组织和正常食管上皮组织中E -cadherin表达水平分别为 5 8.5 %和 93.9% ,两组间有显著性差异(P <0 .0 1) ;E -cadherin在不同性别、年龄组食管癌中的表达水平均无显著性差异 ;在不同部位、分化程度、分期的食管癌中的表达水平也无显著性差异 (P >0 .0 5 )。结论 :食管癌中E -cadherin表达水平明显降低 ,但与食管癌分期、分化程度等临床病理特征无显著性关系。
出处 《泸州医学院学报》 2004年第6期506-507,共2页 Journal of Luzhou Medical College
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