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莫达芬尼酸及莫达芬尼砜的核磁共振波谱研究

A Study on Nuclear Magnetic Resonance Spectrum of Modafinil Acid and Modafinil Sulfone
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摘要 目的 :对莫达芬尼酸和莫达芬尼砜进行核磁共振波谱 (NMR)研究。方法 :采用 1D NMR(1H、13 C NMR、DEPT)和 2D NMR(1H 1HCOSY、HMQC、HMBC)等现代核磁技术检测莫达芬尼酸和莫达尼酸的结构。结果 :归属了莫达芬尼酸和莫达芬尼砜的H、C谱线。结论 :首次报道了莫达芬尼酸和莫达芬尼砜的碳谱数据。 Objective: To study the nuclear magnetic resonance(NMR)spectrum of modafinil acid and modafinil sulfone. Methods: Complete 1H NMR and 13 C NMR assignments of these compounds were carried out using DEPT, HMQC and HMBC techniques. Results: The H and C NMR spectra of the two compounds were sorted. Conclusion: The 13 C NMR data of them are reported for the first time. [
出处 《贵阳医学院学报》 CAS 2004年第6期497-498,共2页 Journal of Guiyang Medical College
关键词 莫达芬尼酸 莫达芬尼砜 磁共振波谱学 modafinil acid modafinil sulfone magnetic resonance spectrum analysis,mass
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参考文献2

  • 1Steven H. Gorman. Determination of modafinil, modafinil acid and modafinil sulfone in human plasma utilizing liquid-liquid extraction and high-performance liquid chromatography[J]. J Chromatography, B 2002, 767, 269-276.
  • 2Elena Carceller, Manuel Merlos, Marta Giral. Synthesis and structure-activity relationships of 1-acyl-4-((2-methyl-3-pyridyl)cyanomthyl)piperazines as PAF antagonists[J].J Med Chem, 1993, 36, 2984-2997.

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