实验性心包炎脂质过氧化物变化及作用探讨

The Changes and Function of Lipid Peroxide in Experimental Pericarditis

目的 :了解心包炎时脂质过氧化物在心肌损害中的作用。方法 :取 2 2只家兔 ,随机分两组。实验组心包腔内注入 30 %尿素 (2ml/kg) ,对照组注入等量生理盐水 ,全部实验动物第 2 1天处死 ,测定血清及心肌丙二醛 (MDA) ,并观察心包、心肌病理组织学及超微结构变化。结果 :术后实验组血清MDA明显上升 ,至 2 1天时维持高浓度 (P <0 0 1) ,较对照组显著上升。结论 :在心包炎病程及心肌损害过程中 ,有脂质过氧化的参与。

Objective: To study the function of lipid peroxide(LPO)in damages of myocardium in pericarditis. Methods: 22 rabbits were divided into 2 groups equally.Group 1 were injected with 30% urea into pericardial cavity and group 2 were injected with 0 9% natrium chloride into pericardial cavity as a control.On the 21th day after the injection,all the rabbits were killed.Levels of malonlialdehyde (MDA) in serum and in myocardial tissue were measured.The pericardial thickness and adhesion were assessed.The pathology and ultra structure changes of myocardium were observed. Results: Serum MDA of group 1 raised obviously after the injection and maintained high levels for 21 days ( P <0 01). The content of myocardial MDA of group 1 was higher than that of group 2 significantly. Conclusion: LPO might be involved in the process of disease developing and myocardial injury in pericarditis. [