煤工尘肺结核患者血清TNF-α水平的临床观察

Clinical Study on the Level of TNF-α in Serum of Coal Miners with Pneumoconiotuberculosis

为了研究煤工尘肺结核患者的机体细胞免疫状况,应用ELISA法对煤工尘肺结核组、煤工尘肺组及肺结核组患者进行血清α肿瘤坏死因子(TNF-α)水平检测,并与健康对照组进行了比较。结果发现煤工尘肺结核组、煤工尘肺组及肺结核组患者血清TNF-α水平均明显低于健康对照组(P<0.01),而这三组患者血清TNF-α水平相差不显著(P>0.05)。煤工尘肺结核组中,随着煤工尘肺期别的增加,血清TNF-α水平也呈明显下降趋势,煤工尘肺 期、 期患者血清中TNF-α水平均显著低于煤工尘肺 期患者血清中TNF-α水平(P<0.05)。因此,煤工尘肺结核患者机体细胞免疫能力明显低下,临床治疗中可考虑使用免疫调节剂进行辅助治疗。

To study the cellular immunological status of coal miners with pneumoconiotuberculosis. ELISA was applied to detection of TNF(-α) in serum of patients in pneumoconiotuberculosis group, pneumoconiosis group and pulmonary tuberculosis group, and comparisons with that in healthy control were made subsequently. The results showed that the levels of TNF(-α) in serum of patients in pneumoconiotuberculosis group, pneumoconiosis group and pulmonary tuberculosis group were significantly lower than that in health control(P<0.01) , while the differences among themselves were not notable (P>0.05). In pneumoconiotuberculosis group, the level of TNF(-α) in serum obviously descended following the increase of pneumoconiosis stage, and the levels of TNF(-α) in serum of patients with pneumoconiosis stageⅡ, stage Ⅲ were significantly lower than that of patients with pneumoconiosis stageⅠ(P<005). So that the cellular immunological competence of coal miners with pneumoconiotuberculosis is obviously low, thus the clinical treatment of auxiliary immunomodulators might be applied to these patients.