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Transgenic technologies for the study of epididymal function 被引量：1

Transgenic technologies for the study of epididymal function
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摘要 Sperm mature and acquire the capacity for fertilization during their transit through the epididymis, however little isknown of the molecular events that comprise sperm maturation. Recent advances in transgenic mouse technology holdpromise for illumination of this process. Most of the existing infertile, transgenic mouse lines seem to have defects inepithelial structure or sperm transport rather than direct defects in the maturation of sperm. Temporally and spatially re-stricted targeted disruptions of epididymal specific genes should provide great insight into the epididymal contribution tosperm maturation. (Asian J Androl 2000; 2: 33 - 38 ) Sperm mature and acquire the capacity for fertilization during their transit through the epididymis, however little isknown of the molecular events that comprise sperm maturation. Recent advances in transgenic mouse technology holdpromise for illumination of this process. Most of the existing infertile, transgenic mouse lines seem to have defects inepithelial structure or sperm transport rather than direct defects in the maturation of sperm. Temporally and spatially re-stricted targeted disruptions of epididymal specific genes should provide great insight into the epididymal contribution tosperm maturation. (Asian J Androl 2000; 2: 33 - 38 )
作者 R.JohnLye BarryT.Hinton
机构地区 Department of Cell Biology
出处 《Asian Journal of Andrology》 SCIE CAS CSCD 2000年第1期33-38,共6页 亚洲男性学杂志（英文版）
关键词 EPIDIDYMIS SPERM MATURATION transgenic organisms FERTILITY epididymis sperm maturation transgenic organisms fertility
分类号 R33 [医药卫生—人体生理学]
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参考文献11

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同被引文献9

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  • 6Clauss A,Lilja H,Lundwall A.A locus on human chromosome 20 contains several genes expressing protease inhibitor domains with homology to whey acidic protein[].Biochemical Journal.2002
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Asian Journal of Andrology
2000年 第1期

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