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地塞米松棕榈酸酯的NMR数据解析 被引量：4

AN NMR STUDY OF DEXAMETHASONE PALMITATE
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摘要 参考地塞米松在D2 O中检测的的1H、19FNMR数据、棕榈酸的1H、13CNMR标准图谱数据和Lindeman Adams经验公式 ,对地塞米松棕榈酸酯进行了1H和13CMNR检测 ,通过DEPT和1H 1HCOSY、HMQC、HMBC等 Dexamethasone palmitate incorporated into liposomes (liposteroid) was developed as a targeting anti-inflammatory drug (limethason) used mainly for treatment of rheumatoid arthritis. In this study, 1D (~1H, ^(13)C NMR and DEPT) and 2D (~1H-~1HCOSY,HMQC and HMBC) NMR spectra of dexamethasone palmitate in chloroform were obtained, assigned and analyzed. The structure of dexamethasone palmitate in chloroform was elucidated by referring to the ~1H and ^(19)F NMR spectra of dexamethason in the aqueous solution, the standard ~1H and ^(13)C NMR spectra of palmitate and the Lindeman-Adams experimental formula.
作者 张海艳 吴鸣建 董建军 付经国 陈涛 赵天增
机构地区 郑州大学化学系 河南省生物技术开发中心 西安力邦企业
出处 《波谱学杂志》 CAS CSCD 北大核心 2004年第4期405-411,共7页 Chinese Journal of Magnetic Resonance
关键词 地塞米松 棕榈酸 NMR技术 ^13C HMBC 检测 数据 化合物 经验公式 解析 NMR, assignments, 2D NMR, dexamethasone palmitate
分类号 O482.53 [理学—固体物理] R284.1 [医药卫生—中药学]
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波谱学杂志
2004年 第4期

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