慢性肺心病患者血浆心钠素测定及其临床意义探讨

DETERMINATION OF PLASMA LEVELS OF CARDIONATRIN IN PATIENTS WITH CHRONIC COR PULMONALE AND STUDY OF ITS CLINICAL SIGNIFICANCE

应用心钠素快速放射免疫分析法观测了52例慢性肺心病患者血浆心钠素浓度变化,结果发现,单纯慢性肺心病组血浆心钠素浓度为93.12±7.2pmol/L,较正常对照组、冠心病组及慢性肺心病合并冠心病组明显降低(P<0.001)。慢性肺心病患者血浆心钠素浓度似与动脉血二氧化碳分压呈负相关趋势,但统计学上无显著意义(r=-0.521,P>0.05),与动脉血氧分压亦无相关性(r=0.185,P>0.05)。并对其临床意义进行了初步探讨。

The plasma levels of cardionatrin were measured in patients with chronic Cor Pulmonale by cardionatrin radio-immunoassay and were compared with those in the control group,the coronary heart disease group and the group with chronic Cot Pulmonale complicated by coronary heart disease.The results showed that the plasma levels of cardionatrin in patients with chronic Cor Pulmonale were lower than those of the control group,the coronary heart disease group and the group with chronic Cot Puimonale complicated by coronary heart disease (P<0.001). It seemed that there was a negative correlation between the plasma levels of cardionatrin in patients with chronic Cor Pulmonale and PaCO_2 (r=0.521),but the correlativity was statistically insignificant (P>0.05).The same was also true with PaO_2(r=0.185,P>0.05).The clinical significance of this is discu- ssed.