摘要
应用组织学方法对激素所致大白鼠股骨头缺血坏死进行了药物预防研究。成年雄性Wistar 大白鼠30只,随机分为3组,A 组只用激素,皆出现典形的股骨头缺血坏死的组织学表现。B 组用激素和冠心平,C 组用激素及降血脂、活血化瘀的中药,结果两组均较A 组轻,C 组最轻。提示经强地松处理的大白鼠可以出现典型的股骨头缺血坏死的组织学表现,降血脂、活血化瘀的药物可以减慢骨坏死的发生,且减轻其坏死程度,中药效果好于冠心平。
The experimental study on prevention of steroid-induced ischemic necrosis offemoral head was done with Wistar mouse.Thirty male adult Wistar mice wereused.The mice were randomly divided into three groups of 10 each.Group A re-ceiced prednisone only.All specimens appeared classic histological features of ische-mic necrosis of the femoral hend.Group B received prednisone and clofibrate.Gro-up C received traditional medicinal herbs and prednisone.The results of experimentshowed that the pathological changes of group B and C are lighter than those ofgroup A.Pathological changed of group C are the lightest.We think Wistar mousetreated by prednisone may appear classic histological features of ischemic necrosisof the femoral head.Reducing serum lipid and improving microcirculation drugs canpostpone the occurrence of osteonecrosis and decrease necrosis degree.Effect of theChinese traditional herbs is better than clofibrate
出处
《青岛医学院学报》
1989年第4期286-289,共4页
Acta Academiae Medicinae Qingdao Universitatis
关键词
激素
股骨头坏死
药物拮抗
组织学
Corticosteroids
Femor head necrosis
Drug antagonism
Histology
Rats,inbred strains
