摘要
研究了硝苯啶、维拉帕米(异搏停)、脑益嗉及汉防已甲素对由钾离子或去甲肾上腺素引起收缩的离体大鼠门静脉作用。这些药物均能使钾离子和去甲肾上腺素剂量-反应曲线呈非平行右移,并降低最大反应值。硝苯啶的PD_2值分别为7.1204和6.3462,维拉帕米为6.1754和7.1049,汉防已甲素为5.4960和5.5121以及脑盖嗉为5.3406和3.8732。上述结果说明这些药物对门静脉具有扩张作用,但作用模式并不一致。
The effects of nifedipine (Nif), verapamil (Ver), tetrandrine (Tet) and cinnarizine (cin) on potassium-or noradrenaline-induced contraction in the isolated strips of rat portal vein were studied. All of these calcium-channel blockers antagonized the actions of potassium and noradrenaline in a non-competitive manner. The shifted the dose-response curves of potassium and noradrenaline to the fight with peak values somewhat declined. The PD_2 values of Nif against potassium and noradrenaline were 7.1204 and 6.3462; those for Ver 6.1753 and 7.1049; those for Tet, 5.4960 and 5.5121; and those for Cin, 5.3406 and 3.8732, respectively. The results suggested that all these agents were effective vasodilators for the portal vein, although their mode of action may not be identical.
出处
《上海第二医科大学学报》
CSCD
1993年第1期35-38,共4页
Acta Universitatis Medicinalis Secondae Shanghai
关键词
钙拮抗剂
大鼠
门静脉
药理学
calcium-channels blockers rat portal vein potassium noradrenaline
