转移因子治疗过敏性哮喘的免疫机理探讨

Studies on the Immune Mechanisms in the Treatment of Allergic Asthma by Transfer Factor

作肯研究转移因子治疗过敏性哮喘的可能免疫机理。结果发现,过敏性哮喘儿童组血清总IgE浓度明显高于慢性气管炎组,两组IgE各为2476.00±1787.87,241.00±112.43IU/ml(?)±SD;有显著性差异(P<0.001);转移因子治疗后,哮喘组降至1132.14±748.86IU/ml、前后相比有统计学意义(P<0.01),与此相反,哮喘组Con A-SC活性则由治疗前10.29%±4.10%增至24.69%±6.90%,亦有统计差异(P<0.01)。此两项免疫参数的变化呈负相关。但哮喘组过敏原皮试阳性百分率与血清总IgE浓度呈正栩关;且与治疗后皮试转阴有关。

This study was to explore the possible immune mechanisms in the treatment of alletrgic asthma by transfer factor (TF). Prior to the TF therapy, the total serum IgE concentration in asthma patients was significantly higher than that in patients with chronic bronchitis (p<0.001). After TFtherapy, the concentration of IgE in asthma patients was also greatly reduced(p<0.01). The changes of these 2 immunological parameters were negatively correlated. In the asthma group, the results of allergen skin test was positively correlated with the total serum IgE coition. Moreover, the reversion of skin test was pamlld to the decrease of total stoma IgE concertration after TF therapy.