左向右分流先心病儿童肺血管紧张素Ⅱ受体的改变

The Change of Angiotensin Ⅱ Receptors in Children with Left-to-right Shunt

目的 探讨左向右分流先天性心脏病患儿肺血管血管紧张素 受体 (AT1R、AT2 R)的表达。方法 2 0例左向右分流先心病患儿术中取肺活检 ,5例儿童尸解正常肺组织作为对照。用免疫组化的方法检测 AT1R、AT2 R表达 ,测定管径为 15～ 10 0 μm肺小血管壁 AT1R、AT2 R染色的 IOD值。结果 先心病患儿肺小血管壁AT1R、AT2 R染色的 IOD值均高于对照组 (P=0 .0 0 0 )。结论 左向右分流先心病患儿肺小血管 AT1R、AT2 R的表达高于正常 ,为 ACEI和

Objective To explore the change of AT1 and AT2 receptors in children with left-to-right shunt. Methods Lung tissue was obtained from 20 children with left-to-right shunt by biopsy during operation, and lung tissue from 5 children by autopsy was used as control. The above specimens were stained by immunohistochemistry techniques for detecting AT1 and AT2 receptors. Histomorphometric study was done to measure the IOD value of pulmonary small vascular wall via the staining of AT1 and AT2 receptors, and the diameter of these vessels was 15-100 μm. Results The IOD values of pulmonary small vascular walls obtained from via the staining of AT1 and AT2 receptors in children with left-to-right shunt were higher than the IOD values in control group (P=0.000). Conclusion The expression of AT1 and AT2 receptors in pulmonary small vascular walls in children with left-to-right shunt was higher than that of the control. It may provide a sound rationale for the pharmacological management of children with left-to-right shunt by use of ACEI or AT1 receptor antagonist.