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环孢素A的药效学研究 被引量:7

Study of cyclosporin A in drug effect
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摘要 目的 介绍环孢素A(CsA)的药效作用及其机制。方法 以国内外的研究为依据 ,对CsA的药效作用及其机制进行了综述。结果 CsA除了通过抑制T细胞胞内信号转导 ,调节免疫应答外 ,还能干扰其他体细胞凋亡的各个环节 ,抑制细胞凋亡 ,并通过不同的信号通路参与细胞的增殖分化过程 ,且呈剂量依赖性。结论 环孢素A不只是免疫抑制剂。
出处 《中国药学杂志》 CAS CSCD 北大核心 2005年第1期1-3,共3页 Chinese Pharmaceutical Journal
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