摘要
Connective tissue growth factor (CTGF) has recently received much attention as a possible key determinant of progressive fibrosis. It promotes tissue fibrosis through different pathways, such as cell proliferation, extracellular matrix accumulation and cell transdifferentiation. A number of regulators of CTGF expression have been identified, including transforming growth factor β, vascular endothelial growth factor, tumor necrosis factor α, etc. The mechanism of profibrotic effect by CTGF was reviewed. [
Connective tissue growth factor (CTGF) has recently received much attention as a possible key determinant of progressive fibrosis. It promotes tissue fibrosis through different pathways, such as cell proliferation, extracellular matrix accumulation and cell transdifferentiation. A number of regulators of CTGF expression have been identified, including transforming growth factor β, vascular endothelial growth factor, tumor necrosis factor α, etc. The mechanism of profibrotic effect by CTGF was reviewed. [
出处
《中国病理生理杂志》
CAS
CSCD
北大核心
2005年第1期199-202,208,共5页
Chinese Journal of Pathophysiology
基金
国家自然科学基金资助项目(30270612)
关键词
结缔组织生长因子
纤维化
转化生长因子Β
Connective tissue growth factor
Fibrosis
Transforming growth factor beta
