p73和c-fos蛋白在血管瘤组织中的表达及意义

The expression of p73 and c-fos protein in hemangioma and its significance

目的 探讨p73和c fos蛋白在血管瘤组织中的发生、发展及临床意义。方法 采用免疫组织化学检测增生期血管瘤、退化期血管瘤及正常皮肤组织中p73和c fos蛋白的表达。结果 在血管瘤增生期中p73和c fos蛋白有较高表达 ;退化期血管瘤和正常皮肤组 ,p73和c fos表达极弱。增生期血管瘤与退化期血管瘤、正常皮肤组分别相比 ,p73和c fos蛋白阳性表达均有统计学意义 (P <0 0 1) ,退化期血管瘤与正常皮肤组 ,p73和c fos蛋白阳性表达的差异均无统计学意义 (P >0 0 5 )。结论 p73和c fos蛋白在血管瘤的发生、发展及其演变过程中起着重要的作用。

Objective To investigate the expression of p73 and c fos protein and its significance in the development of children hemangioma. Methods The quantitative expressions of p73 and c fos protein in hemangioma and normal skin were detected by immunohistochemistry. Results The expressions of p73 and c fos protein were strong in proliferative hemangioma while they were very weak in involutional hemangioma and normal skin. There were significant differences between the proliferative and involutional hemangioma or the normal skin in the expressions of p73 and c fos ( P <0 01). No statistical significances of p73 or c fos expressions were observed between involutional hemangioma and normal skin ( P >0 05). Conclusions P73 and c fos may play an important role in the development and involution of skin hemangioma. ;