舒血宁注射液的毒理学研究

Toxicological study of shuxuening injection

目的 :观察舒血宁注射液的急慢性毒性 ,对该药进行安全性评价。方法 :小鼠连续 7d静脉给药 ,测定药物的半数致死量 (LD50 )。大鼠连续给药 90d后 ,取血 ,做血液生化指标测定 ,进行病理学检查。余下大鼠在停药继续喂养 2周后 ,进行病理组织学检查。结果 :小鼠LD50 为 3 9.5ml/kg ,与对照组比较无显著差异 (P >0 .0 5 )。主要脏器未明显异常。结论 :急慢性毒性实验的结果表明 ,该药安全可靠。

Objective:To investigate the acute and chronic toxicity of shuxuening and evaluate its safety.Methods:Mouses were gavagred shuxuening once a day for seven days. The LD 50 was calculated according to the observed dead and alive conditions. Rats were continuously gavarged shuxuening for 90 days. The remained animals were sacrificed two weeks later, and the main organs were pathologically checked to determine the retarted toxicity.Results: the LD 50 of shuxuening was 39.5ml/kg. Compared with control group (treated with saline), different dosages of Shuxuening didn't cause any significant change in body weight gaining, weight ratios, hematology indexes and plasmic biochemical indicators of rats. The main organs didn't show any abnormarlity in all the histopathologic examinations. Conclusion:The results of acute and chronic toxicological studies show us that the application of shuxuening is safe and reliable.