急性冠脉综合征患者血浆脑钠素水平变化及临床意义

Importance of Brain Natriuretic Peptide Detection in Patients with Acute Coronary Syndrome

目的探讨急性冠脉综合征 (acutecoronarysyndrome,ACS)患者血浆脑钠素 (brainnatriuret icpeptide ,BNP)水平的变化规律及对诊断急性冠脉综合征的临床意义。方法采用酶联免疫吸附法测定ACS患者和对照组血浆BNP浓度 ,将55例ACS患者分为急性心肌梗死组 (acutemyocardialinfarction,AMI组 ,n=25) ,不稳定型心绞痛组 (unstableangina ,UA组 ,n=30) ,分别测定症状发作6h及24h的BNP,并和30例正常健康体检者 (对照组 )作比较。结果①症状发作6h内 ,BNP含量AMI组(60.10±17.10)μg/L和UA组 (34.80±14 .80) μg/L ,均显著高于对照组 (10.60±1.70) μg/L(P<0.01)。②症状发作24h,AMI组BNP(154.00±18.60) μg/L ,UA组BNP(70.31±23.30)μg/L ,显著高于正常对照组 (10.54±1 .80,P<0.01)。结论血浆BNP水平升高与ACS有显著关系 ,并认为血浆BUN水平升高可作为ACS的早期诊断的有效指标。

Objective To study the value of measuring serum level of brain natriuretic peptide(BNP)in paˉtients with acute coronary syndrome(ACS).Methods The serum levels of BNP were determined by enzyme_linked immunoabsorbent assay.Fifty_five patients with ACS were divided into acute myocardial infarction group(group AˉMI,25cases)and unstable angina group(group UA,30cases).BNP was measured and compared in55patients and30healthy controls within6hours and24hours after the onset of symptoms.Results Significantly abnormal concentrations of BNP were observed in group AMI[(60.10±17.10)ug/L and(154.00±18.60)ug/L(P<0.01)]and group UA[(34.80±14.80)ug/L and(70.31±23.30)ug/L(P<0.01)]compared with the controls [(10.60±1.70)ug/L and(10.54±1.80)ug/L] within6hours and24hours after the onset of symptoms.Conˉclusions These results suggested that BNP has a strong association with ACS and BNP can be used as a diagnostic parameter for early diagnosis.