羧甲基茯苓多糖研究进展

Recent Advanced Studies of Carboxymethylpachymaran(CMP)

羧甲基茯苓多糖 (CMP)对小鼠肿瘤U-14 、昆明种小鼠肉瘤 -180 肝癌H2 2 、小鼠Lweis肺癌有抑制作用。CMP能明显增强荷瘤小鼠腹腔巨噬细胞的吞噬功能、小鼠脾抗体分泌细胞数以及特异的抗原结合细胞数及小鼠对牛血清白蛋白诱导的迟发型超敏反应。CMP具有间接抗病毒、保肝与催眠作用。CMP能诱导人血淋巴细胞产生干扰素、白细胞介素、肿瘤坏死因子与粒 -巨噬细胞集落刺激因子。CMP静脉注射小鼠的LD50 为 3 13± 0 14g/kg。CMP 313mg/ (kg·d)连续静脉注射 3个月 ,犬没有呈现毒副作用。CMP 2 5 0mg/kg腹腔注射小鼠无致突变结果、大鼠无致畸胎结果。CMP 313mg/kg静脉注射家兔 ,4

Carboxymethylpachymaran(CMP)has inhibitive function to U_(-14) of tumour of ICR/JCL species little mouse,S_(-180) of sarcomas and liver cancer H_(22) of Kunming Species little mouse and Lewis lung cancer of C_(57) purified species little mouse.CMP can strengthen obviously the engulf function of macrophage cell in abdominal cavity of little mouse with tumour.Increase the quantity of secrete cell of spleen antibody of little mouse and quantity of peculiar antigen combine cell obviously.Strengthen the deferring type hypersensitivity of the little mouse to induce of the blood serum albumen of the ox.CMP has the function of indirect antivirus,protecting the liver and lulling.CMP can induce human peripheral blood lymphocyte to produce interferon,interleukin,tumor necrosis factor and granulocyte macrophage colony-Stimulating factor.The LD_(50) of CMP intravenous injecting on little mouse is(3.13±0.14)g/kg,on dog is 313 mg/(kg·d).Continuous intravenous infection for 3 months,there is no poison side effect occur.Using CMP 250 mg/kg to conduct abdominal cavity injection on little mouse doesn't cause sudden change.Using CMP 250 mg/kg to conduct abdominal cavity injection on little mouse doesn't cause the deformity embryo.Using CMP 313 mg/kg to conduct intravenous injection on rabbit,the CMP in the blood vanish mainly after 48 hours.