摘要
5—氟尿嘧啶(5—FuH)是目前临床常用的一种副作用较大的抗癌药物,当它与金属离子配位后,有改善疗效和降低副作用的可能。本文报道了在无水乙醇体系中,用高氯酸镍(Ni(Cl0_4)_2),5-FuH 的乙醇钠(C_2H_5ONa)合成 Ni(Ⅱ)—5—Fu 配合物的方法及性质的表征,确定配合物的组成,并推断出配合物可能的结构。
5-fluorouracil is an anticancer drug often used in clinic,and its negative effect is rather large.It is possible to increase its curative effect and decrease its negative effect by being complexed with metallic ions.This paper reports the method of synthesizing nickelous(Ⅱ)-5-fluorouracil complex in anhydrous alcohol by nickelous perchlorate, 5-fluorouracil,sodium ethylate,and the characterization of the complex.The compo- nent of this complex is determined as Ni_2(5-Fu)_2(OH)_2(H_2O)_2·1/2C_2H_5OH and its possible structure is deduced.
关键词
高氯酸镍
氟尿嘧啶
配合物
合成
nickelous perchlorate
5-fluorouracil (5-FuH)
complex
thermogravimetric analysis
elementary analysis
infrared spectra
