期刊文献+

蛋白酶体抑制剂筛选模型的建立 被引量:1

Development of a screening assay for proteasome inhibitors
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出处 《中国药理学通报》 CAS CSCD 北大核心 2005年第1期123-124,共2页 Chinese Pharmacological Bulletin
基金 国家重大科技专项"创新药物和中药现代化"中专题"新药筛选及关键技术研究"项目资助课题 (No2002AA2Z3461)
关键词 筛选模型 蛋白酶体抑制剂 Ⅲ期临床试验 PS-341 特异性蛋白 小鼠肿瘤 靶点 抗肿瘤活性 生长 调控作用 proteasome screening model proteasome inhibitor fluorogenic kinetic assay
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参考文献4

  • 1Teicher BA, Ara G, Adams Jet al. The proteasome inhibitor PS-341 in cancer therapy [ J ]. Clin Cancer Res, 1999,5 ( 9 ) : 2638 -45.
  • 2Schmidtke G, Kraft R, Schmidt20 S proteasome biogenesis: TheM et al. Analysis of mammalian maturation of beta-subunits is an ordered two-step mechanism involving autocatalysis[ J]. EMBO J1996,15(24) : 6887 -98.
  • 3Wilson HL, Aldrich HC, Maupin-Furlow J. Halophilic 2O S proteasomes of the archaeon haloferax volcanii : purification, characterization, and gene sequence analysis [ J]. J Bacteriol, 1999,181(18) :5814 -24.
  • 4Lightcap ES, Adams J, Elliott PJ et al, Proteasome inhibition measurements: Clinical application[ J]. Clin Chem,2000,46(5 ) :673-83.

同被引文献14

  • 1周永列,吕亚萍,许武林,胡惟孝.连续荧光监测法测定蛋白酶体活性及其在筛选蛋白酶体抑制剂中的应用[J].中国临床药理学与治疗学,2008,13(10):1127-1133. 被引量:4
  • 2Cerda-Maira F, Darwin KH. The Mycobacterium tuberculosis proteasome: more than just a barrel-shaped protease. Microbes Infect, 2009, 11(14-15): 1150-1155.
  • 3Lin G, Li D, de Carvalho LP, et al. Inhibitors selective for mycobacterial versus human proteasomes. Nature, 2009, 461: 621-626.
  • 4Vandal OH, Nathan CF, Ehrt S. Acid resistance in Myeobacterium tuberculosis. J Bacteriol, 2009, 191 : 47144721.
  • 5Darwin KH, Ehrt S, Gutien'ez-Ramos JC, et al. The proteasome of Mycobacterium tuberculosis is required for resistance to nitric oxide. Science, 2003, 302: 1963-1966.
  • 6Ng VH, Cox JS, Sousa AO, et al. Role of KaIG eatalase- peroxidase in mycobacterlal pathogenesis : countering the phagocyte oxidative burst. Mol Microbiol, 2004, 52: 1291-1302.
  • 7Lightcap ES, McCormack TA, Pien CS, et al. Proteasome inhibition measurements: clinical application. Clin Chem, 2000, 46: 673-683.
  • 8Nam S, Smith DM, Dou QP. Ester bond-containing tea polyphenols potently inhibit proteasome activity in vitro and in vivo. J Biol Chem, 2001,276: 13322-13330.
  • 9Wilson HL, Aldrich HC, Maupin-Furlow J. Halophilic 20S proteasomes of the archaeon Haloferax volcanii: purification, characterization, and gene sequence analysis. J Bacteriol, 1999, 181 : 5814-5824.
  • 10Meng L, Mohan R, Kwok BH, et al. Epoxomicin, a potent and selective proteasome inhibitor, exhibits in vivo antiinflammatory activity. Proc Nad Aeud Sci U S A, 1999, 96: 10403-10408.

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