摘要
间硝基苯甲醛和乙酰乙酸2-甲氧基乙酯在乙酸酐-浓硫酸催化下缩合得到2-(3-硝基亚苄基)乙酰乙酸2-甲氧基乙酯,再在浓盐酸催化下与3-氨基丁烯酸异丙酯在乙醇中闭环得到尼莫地平,总收率80%。
Nimodipine was synthesized from 3-nitrobenzaldehyde by condensation with 2-methoxyethyl aceto- acetate using Ac2O/H2SO4 as catalyst to obtain 2-methoxyethyl 2-(3-nitrobenzylidene)acetoacetate, which subjected to cyclization with isopropyl 3-aminocrotonate in presence of concentratedhydrochloricacid in ethanol with an overall yield of 80%.
出处
《中国医药工业杂志》
CAS
CSCD
北大核心
2005年第1期8-9,共2页
Chinese Journal of Pharmaceuticals
