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生长分化因子-9与卵泡发育 被引量:1

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摘要 GDF-9属于TGF-β超家族,是卵母细胞产生的一种旁分泌因子,在卵巢组织中,GDF-9特定在卵母细胞中表达。除了原始卵泡外的所有卵泡发育时期中均检测GDF-9mRNA。已有实验表明:GDF-9可以诱导原始卵泡募集并促进初级卵泡向小窦前卵泡期过渡,能够刺激卵丘细胞膨胀和产生透明质酸,诱导分化。由于GDF-9具有潜在的诱导原始卵泡生长发动以及促进初级卵泡及以后阶段生长与分化的作用,对GDF-9的深入研究必将增进对卵泡发育的进一步了解,指导临床生殖内分泌疾病的治疗。
出处 《国外医学(计划生育分册)》 2005年第1期24-27,共4页
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