以羟基喜树碱为主联合化疗治疗中晚期恶性肿瘤50例近期疗效观察

Short-term treatment response results in combination chemotherapy based on hydroxyca mptothecin in moderate and advanced 50 tumor patients

为观察以羟基喜树碱(HCPT)为主联合化疗方案对晚期肿瘤的疗效和不良反应。应用HCPT联合顺铂(DDP)、依托泊甙(Vp16)、丝裂霉素(MMC)、多柔比星、5氟尿嘧啶(5FU)等药物组成不同方案治疗中晚期肿瘤患者。结果提示,50例中晚期肿瘤患者治疗总有效率为400%(20/50),对消化道肿瘤有效率为4359%(17/39);不良反应主要为消化道反应、白细胞减少、脱发,但大多为Ⅰ、Ⅱ度,不影响治疗。HCPT联合化疗方案治疗中晚期肿瘤患者安全有效,适合在基层医院使用。

To observe the response and adverse effect on the moderate and advanced tumor based on Hydroxycamptothecin(HCPT)combinating chemotherapeutic regimen.Fifty moderate and advanced tumor patients were treated with varied drug regimens based on HCPT including displatin,etoposide,mitomycin C,adriamycin and 5-fluorouracil.The overall response rate was 40.0% in the moderate and advanced 50 tumor patients, and the vesponse rate 43.59% in digestive tract tmmor. The adverse effects were mainly digestive, side effects, neutropenia, alopecia, which of them were Ⅰ-Ⅱ grade, and had not affect the treatment.The combining regimens based on HCPT are safe and effective in the treatment of moderate and advanced tumor patients, and suit to useage in basic unit hospitals.Chin J Cancer Prev Treat,2005,12(2):145-146