单味生大黄粉治疗危重患儿胃肠功能衰竭临床研究

Clinical study on single Shengdaihuang powder for gastrointestinal failure in children with critically ill

目的:探讨单味生大黄粉治疗危重患儿胃肠功能衰竭的疗效。方法:对71例胃肠功能受损者分为两组,治 疗组36例用生大黄粉,对照组35例用思密达、西米替丁等治疗。同时检测两组细胞因子IL-6、8、TNF的变化。结果:治疗 组有效率91.6％,死亡2例。对照组有效率48.5％,死亡8例,治疗组疗效明显优于对照组。统计学处理差异有显著性意 义(x2=16.96,P<0.005)。病死率对照组明显高于治疗组,统计学处理差异有显著性意义(x2=4.39,P<0.05)。细胞因 子治疗组治疗前IL-6、8、TNF均增高,治疗后IL-6、8、TNF明显降低,统计学处理分别为P<0.001,<0.01,<0.01差异 显著。对照组:治疗前后IL-6、8、TNF无明显变化,统计学处理无差异。结论:单味生大黄粉可降低炎症介质,治疗小儿胃 肠功能衰竭有较好的疗效。

Objective To explore the curative effects of single Shengdaihuang powder for gastrointestinal failure in children with critically ill. Methods Seventy-one cases of gastrointestinal failure were randomly divided into the treatment group and control group. Thirty-six patients in treatment group received Shengdaihuang powder, and thirty-five cases in control group were cured with Smecta and Cimetidine. Before and after treatment, the cytokines IL-6, IL-8, and TNF in all patients were measured. Results The effect rate in treatment group was 91. 6%, significantly higher than that in control group(48. 5%)(x2=16. 96,P<0. 005);the mortality rate in treatment group was significantly lower than that in control group (x2 = 4. 39,P<0. 05). After treatment the cytokines IL-6,IL-8 and TNF in treatment group were significantly decreased (P<0. 001 ;< 0. 01; < 0. 01, respectively); and each factor above in control group was decreased non-significantly (P<0. 05). Conclusion Shengdaihuang powder could lower inflammatory mediators, and it is obviously effective for gastrointestinal failure in children.