不同剂量参麦注射液治疗新生儿缺氧缺血性脑病合并心肌损害的临床研究

Clinical research of diffirent amount of Shenmai Injection in the treatment of hypoxic-ischemic encephalopathy and myocardial injury

目的:观察不同剂量参麦注射液治疗新生儿缺氧缺血性脑病合并心肌损害的临床疗效。方法:将203例伴 有心肌损害的新生儿缺氧缺血性脑病随机分为三组,三组年龄、性别、体重及病情严重程度无差异(P>0.05)。在综合治 疗基础上,对照组给予1-6二磷酸果糖静脉滴注,常规组给予参麦注射液3 mL／(kg·d)静脉滴注,大剂量参麦组7 mL／ (kg·d)静脉滴注。治疗前后对三组患儿生命体征、临床体征、心电图的变化进行分析,并检测相关实验室指标:心肌酶谱 (AST,LDH,CK,CK-MB,a-HBDH),超氧化物歧化酶,谷胱甘酞氧化酶,丙二醛等对三组进行分析。结果:(1)治疗前三 组患儿的检测指标无差异(P>0.05);治疗后,三组检测指标变化有差异。其中大剂量参麦组与对照组、常规参麦组相比 各检测指标恢复或好转的程度均有显著性差异(P<0.01)。结论:大剂量参麦注射液较常规剂量治疗新生儿缺氧缺血性 脑病合并心肌损害有明显疗效,且无明显不良反应。

Objective To investigate the clinical effects of large amount of Shenmai Injection in the treatment in hlypoxic-ischemic encephalopathy and myocardial jury. Methods Two hundred and three patients were individed into three groups. The life signs, clinical symptoms and ECG were compared before and after treatment in these three groups. The laboratory indies were determined. Results There were difference after treatment among these groups (P<0. 05). Conclusion Large amount of Shenmai injection has obvious curative effect than nomal amount of Shenmai injection in the treatment of hypoxic-ischemic encephalopathy and myocardial injury with no side effect.