早期综合干预对新生儿缺氧缺血性脑病预后影响的研究

Study on the influence of earlier period colligation intervention to neonatal hypoxic-ischemic encephalopathy prognosis

目的:探讨早期综合干预对新生儿缺氧缺血性脑病预后的影响。方法:将64例中、重度缺氧缺血性脑病随 机分为干预组40例和对照组24例,干预方法包括新生儿期开始进行视、听、抬头及四肢活动训练,婴儿期进行感知视听、 语言、记忆和动作训练;对脑瘫者进行物理治疗;高压氧疗及应用施普善静脉滴注等。对照组不进行干预,所有病例均于 6,12,18月龄时进行智能发育随访和检测。结果:相同月龄时干预组各能区发育商均高于对照组(P<0.05)。后遗症发生 率明显低于对照组(x2=22.02,P<0.01)。结论:对中、重度缺氧缺血性脑病给予早期持续的干预,能有效地降低后遗症 发生率。

Objective To discuss the influence of earlier period colligation intervention to neonatal hypoxic-ischemic encephalopathy (HIE) prognosis. Methods Sixty-four cases of middle or serious HIE were divieded into intervention group (40 cases) and control group (24 cases). The method of intervention involved the education of seeing, hearing, rasing head and limbs activity from neonatal period,the eaducation of sensation audio,language,memory and activity during infancy, physiotherapy to cerebral palsy patients or suspected cerebral palsy patients ,hyperbaric oxygen-therapy as well as injecting cerebrolysin. Intervention was not done in the control group. All the cases received intellectual development follow-up and detection in the infants of 6,12 and 18 months old. Results The intellectual developed quotient of intervention group was higher than that of the control group at the same month age (P<0. 05). While the sequela incidence of the intervention group was obvious lower than control group(x2 = 22. 02,P<0. 01). Conclusion Giving earlier continuing intervention to middle or serious HIE can effectivly reduce the incidence of sequela.