消化性溃疡中医证型与血浆促胃泌素及生长抑素相关性研究

Relationship between the plasma gastrin, somatotatin and TCM syndromes in peptic ulcer

[目的]探讨血浆促胃泌素(GAS)、生长抑素(SS)水平与消化性溃疡及其中医证型的相关性.[方法]将158例消化性溃疡患者按中医证型分为5型:气滞证33例、郁热证32例、阴虚证32例、虚寒证30例、瘀血证31例;健康体健者30例为对照组.用放射免疫法检测空腹静脉血GAS与SS.[结果]①消化性溃疡组与对照组血浆GAS、SS比较差异有统计学意义(P＜0.05);②血浆GAS、SS水平下降的顺序是:瘀血证＞郁热证＞气滞证＞对照组＞阴虚证＞虚寒证;③中医证型比较:虚证与实症比较差异具有统计学意义(P＜0.05～0.01);而虚证与虚证、实证与实证间比较差异无统计学意义.[结论]GAS、SS可能参与消化性溃疡的病理生理过程;它们的血浆水平可以作为消化性溃疡辨证分型辅助的客观指标.

Objective] To investigate the relationship between plasma gastrin(GAS), somatotatin (SS) and TCM syndromes in peptic ulcer. [Methods] One hundred and fifty eight cases of peptic ulcer were divided into five groups according to clinical characters:33 cases of qi stagnation syndrome,32 cases of stasis heat syndrome, 32 cases of yin deficiency syndrome, 30 cases of asthenic cold syndrome,31 cases of blood stagnation syndrome,30 cases of healthy individuals served as control group. The levels of plasma GAS and SS were measured by radioimmunoassay. [Results] ① The levels of plasma GAS and SS showed a statistical difference between peptic ulcer group and control group(P< 0.05 ); ②The levels of GAS and SS from the highest to the lowest were: blood stagnation syndrome>stasis heat syndrome>qi stagnation syndrome>control group>yin deficiency syndrome>asthenic cold syndrome; ③Comparison between different TCM syndromes: there was statistical difference between deficiency syndrome and excess syndrome (P< 0.05 ~ 0.01 ), no statistical difference between deficiency syndromes or between excess syndromes. [Conclusion] GAS and SS were possibly involved in the pathophysiological process of peptic ulcer. The levels of them could be supportive objective indexes for dividing the TCM syndromes of peptic ulcer.